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Molecular cloning of a putative homolog of proline/arginine-rich antibacterial peptides from porcine bone marrow

FEBS letters / v.336 no.2. 1993, pp.284-288

Author : Pungercar, J. ; Strukelj, B. ; Kopitar, G. ; Renko, M. ; Lenarcic, B. ; Gubensek, F. ; Turk, V.

Abstract : Screening of a porcine bone marrow cDNA library with a PCR-derived probe from rabbit LPS-binding protein CAP18 led to the discovery of two closely related clones. The longer, full-length cDNA clone encodes a 228 amino acid residue protein similar to the family of antibacterial/LPS-binding cationic peptides. In contrast to other hitherto discovered precursors of Pro/Arg-rich peptides from this family, they have a novel, unique structure of the C-terminal region of 100 amino acid residues with a repeating sequence often residues (FPPPNXPGPR, where X = V or F). These precursors could represent a part of the antibacterial peptide repertoire of porcine bone marrow.

Keyword : Antibacterial peptide . Bone marrow . Leukocyte . cDNA

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